Calcium-sensing receptor (CaSR)-mediated anti-inflammatory effects of L-amino acids in intestinal epithelial cells.

@article{Mine2015CalciumsensingR,
  title={Calcium-sensing receptor (CaSR)-mediated anti-inflammatory effects of L-amino acids in intestinal epithelial cells.},
  author={Yoshinori Mine and Hua Zhang},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 45},
  pages={
          9987-95
        }
}
  • Y. Mine, Hua Zhang
  • Published 9 November 2015
  • Biology, Medicine
  • Journal of agricultural and food chemistry
Calcium-sensing receptor (CaSR) plays an essential role in sensing nutrients and monitoring ion balance in the human gut. However, no discovery of CaSR-mediated anti-inflammatory effect of l-amino acids (l-AAs) on the gut system has been reported. The aim of this study is to screen and identify the anti-inflammatory activity of various l-AAs in intestinal epithelial cells (IECs) and stepwise illustrate a possible molecular mechanism for anti-inflammation. We used Caco-2 and HT-29 cell lines to… Expand
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