Calcium release channel RyR2 regulates insulin release and glucose homeostasis.

@article{Santulli2015CalciumRC,
  title={Calcium release channel RyR2 regulates insulin release and glucose homeostasis.},
  author={Gaetano Santulli and Gennaro Pagano and Celestino Sardu and Wenjun Xie and Steven R. Reiken and Salvatore Luca D'ascia and Michele Cannone and Nicola Marziliano and Bruno Trimarco and Theresa A. Guise and Alain Lacampagne and Andrew Robert Marks},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 5},
  pages={1968-78}
}
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional role for RyR2 in β cell insulin secretion and diabetes mellitus remains controversial. Here, we took advantage of rare RyR2 mutations that were identified in patients with a genetic form of exercise-induced… CONTINUE READING

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