Calcium regulation of myosin-I tension sensing.

@article{Lewis2012CalciumRO,
  title={Calcium regulation of myosin-I tension sensing.},
  author={John H. Lewis and Michael J Greenberg and Joseph M. Laakso and Henry Shuman and E Michael Ostap},
  journal={Biophysical journal},
  year={2012},
  volume={102 12},
  pages={2799-807}
}
Myo1b is a myosin that is exquisitely sensitive to tension. Its actin-attachment lifetime increases > 50-fold when its working stroke is opposed by 1 pN of force. The long attachment lifetime of myo1b under load raises the question: how are actin attachments that last >50 s in the presence of force regulated? Like most myosins, forces are transmitted to the myo1b motor through a light-chain binding domain that is structurally stabilized by calmodulin, a calcium-binding protein. Thus, we… CONTINUE READING
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