Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells.

@article{Munshi2002CalciumRO,
  title={Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells.},
  author={Hidayatullah G. Munshi and Yi I. Wu and Edgardo V. Ariztia and M. Sharon Stack},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 44},
  pages={41480-8}
}
Activation of matrix metalloproteinase 2 (MMP-2) has been shown to play a significant role in the behavior of cancer cells, affecting both migration and invasion. The activation process requires multimolecular complex formation involving pro-MMP-2, membrane type 1-MMP (MT1-MMP), and tissue inhibitor of metalloproteinases-2 (TIMP-2). Because calcium is an important regulator of keratinocyte function, we evaluated the effect of calcium on MMP regulation in an oral squamous cell carcinoma line… CONTINUE READING

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