Calcium regulation of growth and differentiation of mouse epidermal cells in culture

@article{Hennings1980CalciumRO,
  title={Calcium regulation of growth and differentiation of mouse epidermal cells in culture},
  author={Henry Hennings and Delores Michael and Christina W. Cheng and Peter M. Steinert and K. L. Holbrook and Stuart H. Yuspa},
  journal={Cell},
  year={1980},
  volume={19},
  pages={245-254}
}
Potassium mediation of calcium-induced terminal differentiation of epidermal cells in culture.
TLDR
This result, along with the inhibitor studies, suggests that potassium plays an important role in epidermal terminal differentiation.
Calcium regulation of growth and differentiation of normal human keratinocytes: Modulation of differentiation competence by stages of growth and extracellular calcium
TLDR
Either or both higher extracellular calcium concentration and the achievement of cell–;cell contacts lead to a coordinate increase of at least two precursors–;involucrin content and transglutaminase activity–;required for cornified envelope formation.
Altered growth kinetics precede calcium-induced differentiation in mouse epidermal cells
TLDR
The results indicate that the calcium switch is followed by a strong reduction in cell flux from G1 whereas the majority of the cells that had left G1 at the time of the switch completed one cell division before cessation of all proliferative activity.
Growth and differentiation of primary tracheal epithelial cells in culture: Regulation by extracellular calcium
TLDR
It is demonstrated that media containing a high calcium content promote conducting airway epithelium to express mucous cell differentiation, while media with low calcium Content promote squamous cell differentiation.
Calcium regulation of normal human mammary epithelial cell growth in culture
TLDR
It is proposed that Ca++ may be an essential trigger for cell divisions that commit a mammary cell to differentiate progressively in a permissive hormonal milieu.
The Cultured Murine Epidermal Keratinocyte and Studies of Differentiation
TLDR
A trigger for epidermal differentiation in vivo and in vitro is likely to be the activation of PI turnover, and the consequent increase in diacylgfycerol and Cai would activate protein kinase C and trigger the differentiation program.
Magnesium and phosphate enrichment of culture medium stimulates the proliferation of epidermal cells from newborn and adult mice
TLDR
The medium containing an optimal phosphate concentration prevented the cell detachment caused by the standard low (1 mM) phosphate medium, and in combination with an elevated magnesium content it markedly increased both DNA synthesis rates and DNA content of the adult cell cultures.
Differential effects of retinoids on DNA synthesis in calcium-regulated murine epidermal keratinocyte cultures.
TLDR
The manipulated rate of proliferation of murine epidermal keratinocytes was manipulated to suggest that Ca++ and low growth factor-regulated keratinocyte cultures are useful for studying the mechanism of hyperproliferation and retinoid actions.
Signal Transduction for Proliferation and Differentiation in Keratinocytes
TLDR
Specific Cao and Cai determine the expression of individual markers of keratinocyte differentiation in vitro and may account for the importance of the Ca2+ gradient for maintaining regulated growth and differentiation of the epidermis in vivo.
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A kinetic analysis of the effects of extracellular concentrations of Ca2+ and Mg2+ on survival and multiplication of normal and transformed human cells in culture finds that cellular multiplication rate and also cellular ‘survival rate’ can be substituted in place of reaction rate in classical enzyme kinetic formulae.
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