Calcium regulation of growth and differentiation in Streptococcus pneumoniae.

  title={Calcium regulation of growth and differentiation in Streptococcus pneumoniae.},
  author={Marie Claude Trombe and Corinne Clav{\'e} and J M Manias},
  journal={Journal of general microbiology},
  volume={138 1},
Streptococcus pneumoniae requires 0.15 mM-Ca2+ in the medium for optimal growth. Increasing the Ca2+ concentration to 1 mM triggers either a differentiative state, competence for genetic transformation during exponential growth, or partial lysis as soon as the cultures enter stationary phase. Genetic and physiological data both suggest that these responses are under the control of activator(s), excreted in the presence of high Ca2+ concentrations. 45Ca2+ transport is also stimulated by the… CONTINUE READING

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