Calcium regulation of exocytosis in PC12 cells.

  title={Calcium regulation of exocytosis in PC12 cells.},
  author={Yucui Chen and Suzie J Scales and V. Nagarjana Devi Duvvuri and Mahesh Murthy and Sejal M. Patel and Howard F Schulman and Richard H. Scheller},
  journal={The Journal of biological chemistry},
  volume={276 28},
The calcium (Ca(2+)) regulation of neurotransmitter release is poorly understood. Here we investigated several aspects of this process in PC12 cells. We first showed that osmotic shock by 1 m sucrose stimulated rapid release of neurotransmitters from intact PC12 cells, indicating that most of the vesicles were docked at the plasma membrane. Second, we further investigated the mechanism of rescue of botulinum neurotoxin E inhibition of release by recombinant SNAP-25 COOH-terminal coil, which is… CONTINUE READING


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