• Corpus ID: 6102164

Calcium regulating activity of 26,27-dialkyl analogs of 1 alpha,25-dihydroxyvitamin D3.

@article{Miyahara1992CalciumRA,
  title={Calcium regulating activity of 26,27-dialkyl analogs of 1 alpha,25-dihydroxyvitamin D3.},
  author={Tatsuro Miyahara and Masahiro Harada and Masaki Miyata and Akemi Sugure and Yumi Ikemoto and Tadanobu Takamura and Shohei Higuchi and Susumu Otomo and Hiroshi Kozuka and Nobuo Ikekawa},
  journal={Calcified tissue international},
  year={1992},
  volume={51 3},
  pages={
          218-22
        }
}
A series of analogs of 1 alpha,25-dihydroxyvitamin D3[1,25(OH)2D3] with alkyl substitutions in 26- and 27-positions were tested for calcium (Ca) regulating activity. The potencies of dialkyl analogs in stimulating bone resorption in neonatal mouse calvaria cultures were the highest in 1 alpha,25-dihydroxy-26,27-dimethylvitamin D3[1,25(OH)2-(Me)2D3], followed by 1,25(OH)2D3, 1 alpha,25-dihydroxy-26,27-diethylvitamin D3[1,25(OH)2(Et)2D3], and 1 alpha,25-dihydroxy-26,27-dipropylvitamin D3[1,25(OH…