Calcium-regulated intramembrane proteolysis of the RAGE receptor.

  title={Calcium-regulated intramembrane proteolysis of the RAGE receptor.},
  author={Arnaud Galichet and Mirjam Weibel and Claus Wilhelm Heizmann},
  journal={Biochemical and biophysical research communications},
  volume={370 1},
The receptor for advanced glycation endproducts (RAGE) interacts with several ligands and is involved in various human diseases. RAGE_v1 or sRAGE, a RAGE splice variant, is secreted and contributes to the removal of RAGE ligands. Because RAGE blockade by specific antibodies directed against RAGE extracellular domains and the use of sRAGE have been proven to… CONTINUE READING