Calcium pumps in health and disease.

@article{Brini2009CalciumPI,
  title={Calcium pumps in health and disease.},
  author={Marisa Brini and Ernesto Carafoli},
  journal={Physiological reviews},
  year={2009},
  volume={89 4},
  pages={
          1341-78
        }
}
Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are thus essential to the correct functioning of the cell machinery. They have high affinity for Ca2+ and can efficiently regulate it down to very low concentration levels. Two of the pumps have been known for decades (the SERCA and PMCA pumps); one (the SPCA pump) has only become known recently. Each pump is the product of a multigene family, the number of isoforms being further increased by alternative… 

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...

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