Calcium pumps in health and disease.
@article{Brini2009CalciumPI, title={Calcium pumps in health and disease.}, author={Marisa Brini and Ernesto Carafoli}, journal={Physiological reviews}, year={2009}, volume={89 4}, pages={ 1341-78 } }
Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are thus essential to the correct functioning of the cell machinery. They have high affinity for Ca2+ and can efficiently regulate it down to very low concentration levels. Two of the pumps have been known for decades (the SERCA and PMCA pumps); one (the SPCA pump) has only become known recently. Each pump is the product of a multigene family, the number of isoforms being further increased by alternative…
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