Calcium plus vitamin D supplementation and the risk of fractures.

  title={Calcium plus vitamin D supplementation and the risk of fractures.},
  author={Rebecca D. Jackson and Andrea Z LaCroix and Margery Gass and Robert B. Wallace and John Robbins and Cora E. Lewis and Tamsen L. Bassford and Shirley A. A. Beresford and Henry R. Black and Patricia Lanoie Blanchette and Denise E. Bonds and Robert L. Brunner and Robert G. Brzyski and Bette Jane Caan and Jane A. Cauley and Rowan Chlebowski and Steve Cummings and Iris A. Granek and J. K. Hays and Gerardo Heiss and Susan Lee Hendrix and Barbara V Howard and Judith Hsia and F. Allan Hubbell and Karen C Johnson and Howard L Judd and Jane Morley Kotchen and Lewis H. Kuller and Robert D. Langer and Norman L. Lasser and Marian C. Limacher and Shari Ludlam and Joann E. Manson and Karen L. Margolis and Joan McGowan and Judith K. Ockene and Michael O'Sullivan and Lawrence S. Phillips and Ross L. Prentice and Gloria E. Sarto and Marcia L. Stefanick and Linda J Van Horn and Jean Wactawski-Wende and Evelyn A Whitlock and Garnet L. Anderson and Annlouise R. Assaf and David Barad},
  journal={The New England journal of medicine},
  volume={354 7},
BACKGROUND The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal. METHODS We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental [corrected] calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an… CONTINUE READING
Highly Influential
This paper has highly influenced 30 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 1,103 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 559 extracted citations

Calcium intake and disease prevention.

Arquivos brasileiros de endocrinologia e metabologia • 2006
View 6 Excerpts
Highly Influenced

25-Hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones.

American journal of public health • 2014
View 6 Excerpts
Highly Influenced

Vitamin D and bone health: Epidemiologic studies.

BoneKEy reports • 2014
View 7 Excerpts
Highly Influenced

Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine.

The Journal of clinical endocrinology and metabolism • 2013
View 4 Excerpts
Highly Influenced

1,104 Citations

Citations per Year
Semantic Scholar estimates that this publication has 1,104 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 115 references

ASHP Therapeutic Position Statement on the Prevention and Treatment of Osteoporosis in Adults

E. J. MacLaughlin, C. L. Raehl
Am J Health Syst Pharm • 2008