Calcium phosphate particle induction of metalloproteinase and mitogenesis: effect of particle sizes.

@article{Cheung1997CalciumPP,
  title={Calcium phosphate particle induction of metalloproteinase and mitogenesis: effect of particle sizes.},
  author={Herman S. Cheung and T R Devine and Walter Hubbard},
  journal={Osteoarthritis and cartilage},
  year={1997},
  volume={5 3},
  pages={
          145-51
        }
}
Calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals [hydroxyapatite (HA), octacalcium phosphate, tricalcium phosphate] are common in osteoarthritis knee effusions, and are often associated with low-grade synovial proliferation and inflammation. Calcium-containing crystals including HA, are known to have a number of biologic effects on culture cells such induction of mitogenesis, stimulation of Prostaglandin E2 (PGE2) production via the phospholipase A2/cyclo… CONTINUE READING
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