Calcium phosphate embedded PLGA nanoparticles: a promising gene delivery vector with high gene loading and transfection efficiency.

@article{Tang2012CalciumPE,
  title={Calcium phosphate embedded PLGA nanoparticles: a promising gene delivery vector with high gene loading and transfection efficiency.},
  author={Jie Tang and Jin-ying Chen and Jing Liu and Min Luo and Ying-Jing Wang and Xia-wei Wei and Xiang Gao and Bi-lan Wang and Yi-bo Liu and Tao Yi and Ai-ping Tong and Xiang-rong Song and Yong-mei Xie and Ying-Lan Zhao and Mingli Xiang and Yuan Huang and Yu Zheng},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={431 1-2},
  pages={210-21}
}
In the purpose of increasing incorporation efficiency and improving the release kinetics of plasmid DNA (pDNA) from poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles, a facile method for the fabrication of calcium phosphate (CaPi) embedded PLGA nanoparticles (CaPi-pDNA-PLGA-NPs) was developed. The effect of several preparation factors on the particle size… CONTINUE READING