Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration.

@article{Peter2005CalciumPD,
  title={Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration.},
  author={Bastian Peter and Dominique P. Pioletti and Samia La{\"i}b and Bruno Bujoli and P Pilet and Pascal Janvier and J{\'e}r{\^o}me Guicheux and Pierre-Yves Zambelli and J M Bouler and Olivier Gauthier},
  journal={Bone},
  year={2005},
  volume={36 1},
  pages={52-60}
}
Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium… CONTINUE READING
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