Calcium oxalate stone disease: role of lipid peroxidation and antioxidants

@article{Selvam2002CalciumOS,
  title={Calcium oxalate stone disease: role of lipid peroxidation and antioxidants},
  author={Ramasamy Selvam},
  journal={Urological Research},
  year={2002},
  volume={30},
  pages={35-47}
}
Membrane injury facilitated the fixation of calcium oxalate crystals and subsequent growth into kidney stones. Oxalate-induced membrane injury was mediated by lipid peroxidation reaction through the generation of oxygen free radicals. In urolithic rat kidney or oxalate exposed cultured cells, both superoxide anion and hydroxyl radicals were generated in excess, causing cellular injury. In hyperoxaluric rat kidney, both superoxide and H2O2-generating enzymes such as glycolic acid oxidase (GAO… CONTINUE READING