Calcium orchestrates apoptosis

@article{Mattson2003CalciumOA,
  title={Calcium orchestrates apoptosis},
  author={Mark P. Mattson and Sic L. Chan},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={1041-1043}
}
Apoptosis is a feature of many diseases and is critical for the sculpting and maintenance of tissues. New work demonstrates that calcium released from the endoplasmic reticulum synchronizes the mass exodus of cytochrome c from the mitochondria, a phenomenon that coordinates apoptosis. 
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440 Citations

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TLDR
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MEDIATION OF CHEMOTHERAPY-INDUCED APOPTOSIS BY THE LYSOSOMAL PROTEASE CATHEPSIN D
TLDR
It is demonstrated that cathepsin D is an important component of the apoptotic pathway and that it acts via an intermediary cytosolic factor to promote cytochrome c release and caspase activation during chemotherapy-induced apoptosis.
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TLDR
Because of their distinct mechanisms for Cyt c release, both the mPT and proapoptotic proteins should be targeted for effective clinical intervention in CNS disorders involving apoptosis.
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TLDR
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