Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co‐exposures of aflatoxin and fumonisin

  title={Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co‐exposures of aflatoxin and fumonisin},
  author={N. Mitchell and K. Xue and Shuhan Lin and A. Marroqu{\'i}n-Cardona and K. Brown and S. Elmore and Lili Tang and A. Romoser and W. Gelderblom and Jia-Sheng Wang and T. Phillips},
  journal={Journal of Applied Toxicology},
Aflatoxins (AFs) and fumonisins (FBs) can co‐contaminate foodstuffs and have been associated with hepatocellular and esophageal carcinomas in humans at high risk for exposure. One strategy to reduce exposure (and toxicity) from contaminated foodstuffs is the dietary inclusion of a montmorillonite clay (UPSN) that binds AFs and FBs in the gastrointestinal tract. In this study, the binding capacity of UPSN was evaluated for AFB1, FB1 and a combination thereof in Fischer 344 rats. Rats were pre… Expand
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