Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke.

@article{Brown2002CalciumMO,
  title={Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke.},
  author={Rachel Clare Brown and Thomas P Davis},
  journal={Stroke},
  year={2002},
  volume={33 6},
  pages={1706-11}
}
BACKGROUND This review deals with the role of calcium in endothelial cell junctions of the blood-brain barrier (BBB). Calcium is critical for adherens junction function, but it appears that calcium is also important in regulating tight junction function necessary for the barrier characteristics of cerebral microvessels. SUMMARY OF REVIEW The BBB is critical for brain homeostasis and is located at the cerebral microvessel endothelial cells. These endothelial cells maintain their barrier… CONTINUE READING

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