Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors.

@article{Vernino1992CalciumMA,
  title={Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors.},
  author={Steven Vernino and M S Amador and Charles W Luetje and Jim Patrick and John A Dani},
  journal={Neuron},
  year={1992},
  volume={8 1},
  pages={127-34}
}
Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater for neuronal than for muscle nAChRs. A second difference between the receptor types is that neuronal nAChRs are potently modulated by physiological levels of external Ca2… CONTINUE READING
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