Calcium mobilization induced by endothelins and sarafotoxin in cultured canine tracheal smooth muscle cells

@article{Yang1994CalciumMI,
  title={Calcium mobilization induced by endothelins and sarafotoxin in cultured canine tracheal smooth muscle cells},
  author={Chuen Mao Yang and Y L Yo and Richard Ong and Jen Tsung Hsieh and H L Tsao},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1994},
  volume={350},
  pages={68-76}
}
Endothelins (ETs)- and sarafotoxin (S6b)-induced rises in intracellular Ca2+ concentration ([Ca2+]i) were monitored in cultured canine tracheal smooth muscle cells by using a fluorescent Ca2+ indicator fura-2. ET-1, ET-2, ET-3 and S6b elicited an initial transient peak and followed by a sustained elevation of [Ca2+]i, with half-maximal effect (EC50) of 18, 20, 38 and 21 nM, respectively. BQ-123, an ETA receptor antagonist, had a high affinity to block the rise in [Ca2+]i response to ET-1, ET-2… CONTINUE READING

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