Calcium mobilization in human platelets by receptor agonists and calcium-ATPase inhibitors.

@article{Brne1991CalciumMI,
  title={Calcium mobilization in human platelets by receptor agonists and calcium-ATPase inhibitors.},
  author={Bernhard Br{\"u}ne and Volker Ullrich},
  journal={FEBS letters},
  year={1991},
  volume={284 1},
  pages={1-4}
}
Inhibitors of the endoplasmic reticulum Ca(2+)-ATPase like thapsigargin (TG) and 2,5-di (tert-butyl)-1,4-benzohydroquinone (tBuBHQ) cause increases in cytosolic calcium in intact human platelets resulting from prevention of reuptake. A maximal concentration of TG (0.2 microM) mobilized 100% of sequestered Ca2+ compared to the action of a receptor agonist like thrombin (0.1 U/ml). A maximal dose of tBuBHQ (50 microM) stimulated release of about 40% of intracellular calcium compared to thrombin… CONTINUE READING
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