Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta.

@article{Tsuneki2000CalciumME,
  title={Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta.},
  author={Hiroshi Tsuneki and Rabih Klink and Cl{\'e}ment L{\'e}na and Henri Korn and Jean Pierre Changeux},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 7},
  pages={2475-85}
}
Nicotinic acetylcholine receptors (nAChRs) are expressed in the midbrain ascending dopaminergic system, a target of many addictive drugs. Here we assessed the intracellular Ca2+ level by imaging fura-2-loaded cells in substantia nigra pars compacta in mouse brain slices, and we examined the influence on this level of prolonged exposures to nicotine using mice lacking the nAChR beta2-subunit. In control cells, superfusion with nicotine (10-100 microM) caused a long-lasting rise of intracellular… CONTINUE READING
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