Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.

@article{Quintana2011CalciumMA,
  title={Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.},
  author={Ariel Quintana and Mathias Pasche and Christian Junker and Dalia M M Al-Ansary and Heiko Rieger and Carsten Kummerow and Luc{\'i}a N{\'u}{\~n}ez and J. Carlos Villalobos and Paul Meraner and Ute Becherer and Jens Rettig and Barbara A Niemeyer and Markus Hoth},
  journal={The EMBO journal},
  year={2011},
  volume={30 19},
  pages={
          3895-912
        }
}
Cell polarization enables restriction of signalling into microdomains. Polarization of lymphocytes following formation of a mature immunological synapse (IS) is essential for calcium-dependent T-cell activation. Here, we analyse calcium microdomains at the IS with total internal reflection fluorescence microscopy. We find that the subplasmalemmal calcium signal following IS formation is sufficiently low to prevent calcium-dependent inactivation of ORAI channels. This is achieved by localizing… CONTINUE READING
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