Calcium mediates one of the signals required for interleukin 1 and 2 production by murine cell lines.

Abstract

The murine T lymphoma cell line EL-4 can be induced to produce interleukin 2 (IL-2) by concurrent stimulation with interleukin 1 (IL-1) and a T-cell lectin such as phytohemagglutinin (PHA) or concanavalin A (Con A). The results presented here demonstrate that the requirement for the lectin, but not IL-1, could be completely replaced by the calcium ionophore… (More)

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