Calcium mediates gastrin-induced gastric histamine release in the rat.

@article{Sandvik1993CalciumMG,
  title={Calcium mediates gastrin-induced gastric histamine release in the rat.},
  author={Arne K. Sandvik and Eiliv Brenna and H L Waldum},
  journal={The American journal of physiology},
  year={1993},
  volume={264 1 Pt 1},
  pages={G51-6}
}
This study examined the second messenger system responsible for gastrin-induced histamine release from the rat stomach. We examined the effect of different concentrations of ionized calcium, the calcium-channel blockers verapamil and nicardipine, and the intracellular calcium-chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid/acetoxymethyl ester (BAPTA/AM) on gastrin-stimulated histamine release in the totally isolated vascularly perfused rat stomach. Moreover, the effect on… CONTINUE READING