Calcium-mediated parathyroid hormone release changes in patients treated with the calcimimetic agent cinacalcet.

@article{Francisco2008CalciummediatedPH,
  title={Calcium-mediated parathyroid hormone release changes in patients treated with the calcimimetic agent cinacalcet.},
  author={Angel L. M. de Francisco and Maria Izquierdo and John W. Cunningham and Celestino Pi{\~n}era and Rosa Palomar and Gema Fern{\'a}ndez Fresnedo and Jos{\'e} Antonio Garc{\'i}a Amado and Mayte Garc{\'i}a Unzueta and Manuel Arias},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 9},
  pages={
          2895-901
        }
}
BACKGROUND The parathyroid-calcium (Ca(2+)-PTH) curve expresses modulation of parathyroid hormone (PTH) secretion by the parathyroid gland as a function of changing extracellular Ca(2+) concentration. Patients with hyperparathyroidism (HPT) show a rightward shift of the curve compared with controls, suggesting a reduced sensitivity of parathyroid cells to Ca(2+). Increasing the sensitivity of the parathyroid gland to extracellular Ca(2+) by manipulation of the Ca(2+)-sensing receptor (CaR) may… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl.

  • The Journal of pharmacology and experimental therapeutics
  • 2004