Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse.

  title={Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse.},
  author={Jonathan D. Glass and B L Schryer and John Wesley Griffin},
  journal={Journal of neurochemistry},
  volume={62 6},
The C57BL/Ola (Ola) mouse is a mutant substrain in which transected axons undergo very slow Wallerian degeneration. Because axonal degradation during Wallerian degeneration is calcium dependent, we tested whether Ola axons are susceptible to calcium-mediated axonal degeneration by comparing neurofilament degradation between Ola and C57BL/6 mice in sciatic nerve explants. Using immunoblot analysis of neurofilament degradation and electron microscopy we found that as in normal axons, axonal… CONTINUE READING

From This Paper

Topics from this paper.
20 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…