Calcium-mediated activation of pyruvate dehydrogenase in severely injured postischemic myocardium.

@article{Terrand2001CalciummediatedAO,
  title={Calcium-mediated activation of pyruvate dehydrogenase in severely injured postischemic myocardium.},
  author={J{\'e}r{\^o}me Terrand and Ir{\`e}ne Papageorgiou and Nathalie Rosenblatt-Velin and Rolf Lerch},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 2},
  pages={
          H722-30
        }
}
Indirect evidence suggests that activity of pyruvate dehydrogenase (PDH) influences recovery of the myocardium after transient ischemia. The present study examined the relationship between postischemic injury and activity of PDH and the role of mitochondrial calcium uptake for observed changes in PDH activity. Isovolumically beating isolated rat hearts perfused with erythrocyte-enriched buffer containing glucose, palmitate, and insulin were submitted to either 20 or 35 min of no-flow ischemia… CONTINUE READING

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