Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region.

@article{Vezzoli2010CalciumKS,
  title={Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region.},
  author={Giuseppe Vezzoli and Annalisa Terranegra and Teresa Arcidiacono and Giovanni Gambaro and Luciano Milanesi and Ettore Mosca and Laura Soldati},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2010},
  volume={25 7},
  pages={2245-52}
}
BACKGROUND Calcium-sensing receptor gene (CaSR) is a candidate to explain susceptibility to calcium kidney stones. Thus, we studied CaSR gene single-nucleotide polymorphisms (SNPs) and haplotypes associated with stones. METHODS Four hundred and sixty-three calcium stone formers and 213 healthy controls were genotyped for 21 SNPs mapping the whole CaSR gene. CaSR gene structure was studied. SNPs and haplotypes were analysed for association with stones. RESULTS Three haplotype blocks were… CONTINUE READING
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