Calcium ions in neuronal degeneration.

  title={Calcium ions in neuronal degeneration.},
  author={Urszula Wojda and Elzbieta Salinska and Jacek Kuźnicki},
  journal={IUBMB life},
  volume={60 9},
Neuronal Ca(2+) homeostasis and Ca(2+) signaling regulate multiple neuronal functions, including synaptic transmission, plasticity, and cell survival. Therefore disturbances in Ca(2+) homeostasis can affect the well-being of the neuron in different ways and to various degrees. Ca(2+) homeostasis undergoes subtle dysregulation in the physiological ageing. Products of energy metabolism accumulating with age together with oxidative stress gradually impair Ca(2+) homeostasis, making neurons more… CONTINUE READING


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Ageing and the brain

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