Calcium ionophore and phorbol myristate acetate synergistically inhibited proteoglycan biosynthesis in articular chondrocytes by prostaglandin independent mechanism.

@article{Bouakka1988CalciumIA,
  title={Calcium ionophore and phorbol myristate acetate synergistically inhibited proteoglycan biosynthesis in articular chondrocytes by prostaglandin independent mechanism.},
  author={Mohammed Bouakka and Paulette Legendre and V. Jouis and Monique Langris and Dominique Bourel and G. Loyau and Jean Claude Bocquet},
  journal={Biochemical and biophysical research communications},
  year={1988},
  volume={153 2},
  pages={
          690-8
        }
}
In rabbit articular chondrocytes, phorbol myristate acetate (PMA), 1,2-dioctanoyl-sn-glycerol (DG) and calcium ionophore (A23187), reduced the proteoglycan synthesis, in a dose-dependent manner. The combined treatment by PMA and A23187 resulted in an enhanced inhibition of proteoglycan production, indicating a synergistic effect. In presence of PMA or A23187, the release of prostaglandin E2 (PGE2) was dramatically increased. The addition of indomethacin and BW755c to chondrocytes stimulated by… CONTINUE READING
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