Calcium ionophore X-537A increases spontaneous and phasic quantal release of acetylcholine at frog neuromuscular junction

@article{Kita1974CalciumIX,
  title={Calcium ionophore X-537A increases spontaneous and phasic quantal release of acetylcholine at frog neuromuscular junction},
  author={H. Kita and W. Kloot},
  journal={Nature},
  year={1974},
  volume={250},
  pages={658-660}
}
  • H. Kita, W. Kloot
  • Published 1974
  • Chemistry, Medicine
  • Nature
  • TRANSMITTER release from nerve endings is believed to be triggered by the influx of Ca2+, which is thought to enter the terminal as a result of an increase in conductance produced by the action potential1. At the neuromuscular junction the evidence for the role of Ca2+ is largely indirect, based on changes in endplate potential (e.p.p.) amplitude following variations in [Ca2+]0. Miledi2 showed that microinjection of Ca2+ into the presynaptic terminal at the synapse of the squid giant axon… CONTINUE READING
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