Calcium ionophore A23187 as a regulator of gene expression in mammalian cells

@article{Resendez1986CalciumIA,
  title={Calcium ionophore A23187 as a regulator of gene expression in mammalian cells},
  author={Elpidio Resendez and J. Ting and Kyo Sun Kim and Scott Wooden and Amy Si-Ying Lee},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={2145 - 2152}
}
The calcium ionophore A23187 can reversibly induce the expression of two glucose-regulated genes, p3C5 and p4A3. This induction requires a continuous presence of the ionophore for over 2 h. Although extracellular Ca2+ is important for the optimal effect of A23187, it is not necessary for the induction, since a similar response with a lower magnitude can be triggered in cells cultured in low Ca2+ medium buffered with EGTA. Both the basal and induced levels of p3C5 and p4A3 transcripts can be… CONTINUE READING

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