Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential.

@article{Scott1980CalciumionTB,
  title={Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential.},
  author={Iain Scott and Karl E Akerman and Dr M. Gary Nicholls},
  journal={The Biochemical journal},
  year={1980},
  volume={192 3},
  pages={873-80}
}
The association of Ca2+ with isolated nerve endings (synaptosomes) is investigated and resolved into two components, that bound to the outer surface of the plasma membrane and that transported across the plasma membrane. When synaptosomes are added directly to a Ca2+-containing medium, there is an initial rapid uptake of Ca2+ across the plasma membrane, followed by a slow uptake that proceeds for 20 min. The rapid phase is not observed if the synaptosomes are initially pre-incubated in a Ca2… CONTINUE READING
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