Calcium instabilities in mammalian cardiomyocyte networks.

@article{Bien2006CalciumII,
  title={Calcium instabilities in mammalian cardiomyocyte networks.},
  author={Harold Bien and Lihong Yin and Emilia Entcheva},
  journal={Biophysical journal},
  year={2006},
  volume={90 7},
  pages={2628-40}
}
The degeneration of a regular heart rhythm into fibrillation (a chaotic or chaos-like sequence) can proceed via several classical routes described by nonlinear dynamics: period-doubling, quasiperiodicity, or intermittency. In this study, we experimentally examine one aspect of cardiac excitation dynamics, the long-term evolution of intracellular calcium signals in cultured cardiomyocyte networks subjected to increasingly faster pacing rates via field stimulation. In this spatially extended… CONTINUE READING

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