Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

@article{Denton2016CalciuminsensitiveSV,
  title={Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.},
  author={Richard M. Denton and Timothy J. Pullen and Craig T. Armstrong and Kate J Heesom and Guy A Rutter},
  journal={The Biochemical journal},
  year={2016},
  volume={473 9},
  pages={
          1165-78
        }
}
The 2-oxoglutarate dehydrogenase (OGDH) complex is an important control point in vertebrate mitochondrial oxidative metabolism, including in the citrate cycle and catabolism of alternative fuels including glutamine. It is subject to allosteric regulation by NADH and the ATP/ADP ratio, and by Ca(2+) through binding to the E1 subunit. The latter involves a unique Ca(2+)-binding site which includes D(114)ADLD (site 1). Here, we describe three splice variants of E1 in which either the exon… CONTINUE READING