Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus.

@article{Arrizubieta2004CalciumIB,
  title={Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus.},
  author={Mar{\'i}a Jes{\'u}s Arrizubieta and Alejandro Toledo-Arana and Beatriz Amorena and Jos{\'e} R Penad{\'e}s and I{\~n}igo Lasa},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 22},
  pages={
          7490-8
        }
}
Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the amino acid sequence of Bap prompted us to investigate the effect of calcium on the multicellular behavior of Bap-expressing staphylococci. We found that addition of millimolar amounts of calcium to the growth media inhibited intercellular adhesion of and biofilm formation by… CONTINUE READING

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