Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts

@article{Ito1999CalciumIT,
  title={Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts},
  author={Kiyoharu Ito and Isamu Okamoto and Norie Araki and Yoshiaki Kawano and Mitsuyoshi Nakao and Shigetoshi Fujiyama and Kimio Tomita and Tatsuyuki Mimori and Hideyuki Saya},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={7080-7090}
}
Cadherins are major cell – cell adhesion molecules in both tumor and normal tissues. Although serum levels of soluble E-cadherin have been shown to be higher in the cancer patients than in healthy volunteers, the detail mechanism regulating release of soluble E-cadherin remains to be elucidated. Here we show that the ectodomain of E-cadherin is proteolytically cleaved from some cancer cells by a membrane-bound metalloprotease to yield soluble form, and the residual membrane-tethered cleavage… CONTINUE READING
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