Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells.

@article{Halabisky2000CalciumIT,
  title={Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells.},
  author={Brian Halabisky and Daniel D Friedman and Milan Radojicic and Ben W. Strowbridge},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 13},
  pages={5124-34}
}
Recurrent inhibition in olfactory bulb mitral cells is mediated via reciprocal dendrodendritic synapses with granule cells. Although GABAergic granule cells express both NMDA and non-NMDA glutamate receptors, dendrodendritic inhibition (DDI) relies on the activation of NMDA receptors. Using whole-cell recordings from rat olfactory bulb slices, we now show that olfactory NMDA receptors have a dual role; they depolarize granule cell spines, and they provide a source of calcium that can evoke GABA… CONTINUE READING
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