Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.

@article{Chen2011CalciumIT,
  title={Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.},
  author={Xiongwen Chen and Hiroyuki Nakayama and Xiaoying Zhang and Xiaojie Ai and David M. Harris and Mingxin Tang and Hongyu Zhang and Christopher C. T. Szeto and Kathryn Stockbower and Remus M. Berretta and Andrea D. Eckhart and Walter J Koch and Jeffery D Molkentin and Steven R. Houser},
  journal={Journal of molecular and cellular cardiology},
  year={2011},
  volume={50 3},
  pages={460-70}
}
Pathological cardiac hypertrophy (PCH) is associated with the development of arrhythmia and congestive heart failure. While calcium (Ca(2+)) is implicated in hypertrophic signaling pathways, the specific role of Ca(2+) influx through the L-type Ca(2+) channel (I(Ca-L)) has been controversial and is the topic of this study. To determine if and how sustained increases in I(Ca-L) induce PCH, transgenic mouse models with low (LE) and high (HE) expression levels of the β2a subunit of Ca(2+) channels… CONTINUE READING
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