Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

@inproceedings{Hartzell2016CalciumIT,
  title={Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse},
  author={Catherine A Hartzell and Katarzyna Izabela Jankowska and Janis K Burkhardt and Richard S Lewis},
  booktitle={eLife},
  year={2016}
}
T cell receptor (TCR) engagement opens Ca(2+) release-activated Ca(2+) (CRAC) channels and triggers formation of an immune synapse between T cells and antigen-presenting cells. At the synapse, actin reorganizes into a concentric lamellipod and lamella with retrograde actin flow that helps regulate the intensity and duration of TCR signaling. We find that Ca(2+) influx is required to drive actin organization and dynamics at the synapse. Calcium acts by promoting actin depolymerization and… CONTINUE READING

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  • 2017
VIEW 1 EXCERPT
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References

Publications referenced by this paper.
SHOWING 1-10 OF 108 REFERENCES

epithelial cells

SC Bunnell, V Kapoor, RP Trible, W Zhang, LE. Samelson
  • Journal of Cell Science
  • 2001
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

The immunological synapse.

  • Cancer immunology research
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

T-cell activation. Immunological Reviews 256:80–94

A Babich, S Li, +3 authors JK. Burkhardt
  • 2012
VIEW 19 EXCERPTS
HIGHLY INFLUENTIAL

Microbiology and Immunology 340:81–106

CH Yu, HJ Wu, +4 authors C. Yu
  • 2010
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

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