Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses.

@article{Takahashi2001CalciumID,
  title={Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses.},
  author={Masataka Takahashi and Rachel E. Freed and Trillium Blackmer and Samantha Alford},
  journal={The Journal of physiology},
  year={2001},
  volume={532 Pt 2},
  pages={
          323-36
        }
}
1. The mechanisms by which 5-hydroxytryptamine (5-HT) depresses transmitter release from lamprey reticulospinal axons were investigated. These axons make glutamatergic synapses onto spinal ventral horn neurons. 5-HT reduces release at these synapses, yet the mechanisms remain unclear. 2. Excitatory postsynaptic currents (EPSCs) evoked by stimulation of reticulospinal axons were recorded in ventral horn neurons. 5-HT depressed the EPSCs in a dose-dependent manner with an apparent Km of 2.3… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Presynaptic G-protein-coupled receptors dynamically modify vesicle fusion, synaptic cleft glutamate concentrations, and motor behavior.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2009
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2014
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED