Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.

  title={Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.},
  author={Beverly A. Rzigalinski and Karen A Willoughby and Seth Hoffman and John R Falck and Earl F. Ellis},
  journal={The Journal of biological chemistry},
  volume={274 1},
We present evidence in astrocytes that 5,6-epoxyeicosatrienoic acid, a cytochrome P450 epoxygenase metabolite of arachidonic acid, may be a component of calcium influx factor, the elusive link between release of Ca2+ from intracellular stores and capacitative Ca2+ influx. Capacitative influx of extracellular Ca2+ was inhibited by blockade of the two critical steps in epoxyeicosatrienoic acid synthesis: release of arachidonic acid from phospholipid stores by cytosolic phospholipase A2 and… CONTINUE READING

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