Calcium influx and transmitter release in a fast CNS synapse

@article{Borst1996CalciumIA,
  title={Calcium influx and transmitter release in a fast CNS synapse},
  author={J. Gerard G. Borst and Bert J. Sakmann},
  journal={Nature},
  year={1996},
  volume={383},
  pages={431-434}
}
CALCIUM entry through presynaptic calcium channels controls the release of neurotransmitter1. It is not known whether the putative calcium sensor that triggers this rapid neurotransmitter release is close enough to be activated by the large increase in the Ca2+ concentration (calcium 'domain') reached within nanometres of a single calcium channel or whether many channels have to open2. We tested this in a calyx-type synapse in the rat medial nucleus of the trapezoid body. We compared the… CONTINUE READING
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