Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis.

@article{Hoffmann2013CalciumIA,
  title={Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis.},
  author={Dorit B. Hoffmann and Sarah K. Williams and Jovana Bojcevski and Andreas Mueller and Christine Stadelmann and Vinogran Naidoo and Ben A Bahr and Ricarda Diem and Richard Fairless},
  journal={Journal of neuropathology and experimental neurology},
  year={2013},
  volume={72 8},
  pages={745-57}
}
Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Recently, the neurodegenerative component of multiple sclerosis has come under focus particularly because permanent disability in patients correlates well with neurodegeneration; and observations in both humans and multiple sclerosis animal models highlight neurodegeneration of retinal ganglion cells as an early event. After myelin oligodendrocyte glycoprotein immunization of Brown… CONTINUE READING
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