Calcium induced changes of calcitonin mRNA levels in the normal rat

Calcitonin, the hypocalcemic hypophosphatemic hormone, is synthesized by the thyroidal C cells in mammals. The sequences of its gene (Jonas et a1.,1985) and the biosynthetic precursor (Jacobs et a1.,1981) is established in rats. In vivo administration of calcium, a potent calcitonin (CT) secretagogue, to rats induces a rapid increase in the translational… CONTINUE READING