Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line.

Abstract

The rd mouse, an accepted animal model for photoreceptor degeneration in retinitis pigmentosa, has a recessive mutation for the gene encoding the beta-subunit of the cGMP phosphodiesterase. This mutation results in high levels of cGMP, which leaves an increased number of the cGMP-gated channels in the open state, thus allowing intracellular calcium (Ca(2… (More)
DOI: 10.1074/jbc.A117.401037

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@article{Sharma2004CalciuminducedCM, title={Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line.}, author={Ashish K. Sharma and B{\"a}rbel Rohrer}, journal={The Journal of biological chemistry}, year={2004}, volume={279 34}, pages={35564-72} }