Calcium-induced calcium release mechanism in guinea pig taenia caeci

  title={Calcium-induced calcium release mechanism in guinea pig taenia caeci},
  author={Masamitsu Iino},
  journal={The Journal of General Physiology},
  pages={363 - 383}
Fura-2 was used to measure the amount of Ca released from the intracellular Ca store of a saponin-skinned smooth muscle fiber bundle of the guinea pig taenia caeci (width, 150-250 microns) placed in a capillary cuvette at 20-22 degrees C. The amount of Ca actively loaded into the store was assayed when released by the application of 50 mM caffeine and/or 10 microM inositol 1,4,5-trisphosphate (IP3) in the absence of ATP, and was found to have a biphasic dependence on the loading [Ca2+] with a… CONTINUE READING