Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.

@article{Cedars2009CalciumindependentPI,
  title={Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.},
  author={Ari M Cedars and Christopher M. Jenkins and David J. Mancuso and Richard W. Gross},
  journal={Journal of cardiovascular pharmacology},
  year={2009},
  volume={53 4},
  pages={277-89}
}
Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in the maintenance of membrane structure and function, thereby fundamentally integrating dynamic alterations in myocardial performance with membrane composition and dynamics. The major phospholipases in myocardium belong to a family of proteins known as calcium-independent phospholipases (iPLA2s). In addition to their role in… CONTINUE READING