Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid.

@article{Kijima1988CalciumindependentIO,
  title={Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid.},
  author={Hiromasa Kijima and Nobukazu Tanabe},
  journal={The Journal of physiology},
  year={1988},
  volume={403},
  pages={135-49}
}
1. Application of an amino-residue-modifying reagent, 2,4,6-trinitrobenzene-1-sulphonic acid (TNBS), to the frog neuromuscular junction in high-magnesium Ringer solution rapidly increased both the amplitude of nerve-evoked end-plate potentials (EPPs) and the frequency of miniature end-plate potentials (MEPPs). These showed a similar initial time course and reached a maximum 3-7 min and about 10 min, respectively, after the start of application of 2 mM-TNBS. Then, the EPP amplitude decreased… CONTINUE READING